From IC₅₀ readings to a strong-inhibitor designation.
A medicinal chemist has six IC₅₀ readings of compound EIG_0291 and wants the chain to attest "EIG_0291 is a strong CDK2 inhibitor" — only by mechanical derivation, not by author assertion. The statistics institution emits a strictly statistical conclusion; a chain-resident domain bridge translates it to the medicinal-chemistry vocabulary; a literature rule specialises at the compound; the kernel type-checks the composition. The final conclusion carries an audit trail that walks back to the raw plate readings.